8y4l

Structural highlights

Function

MED25_ARATH Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Positive regulator of shade avoidance and of jasmonate signaling. Acts in repression of PhyB-mediated light signaling and regulates the expression of FLOWERING LOCUS T (FT) and of CONSTANS (CO).^{[1] [2] [3] [4] [5] [6]}

References

1. ↑ Cerdán PD, Chory J. Regulation of flowering time by light quality. Nature. 2003 Jun 19;423(6942):881-5. PMID:12815435 doi:10.1038/nature01636
2. ↑ Bäckström S, Elfving N, Nilsson R, Wingsle G, Björklund S. Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit. Mol Cell. 2007 Jun 8;26(5):717-29. PMID:17560376 doi:10.1016/j.molcel.2007.05.007
3. ↑ Wollenberg AC, Strasser B, Cerdán PD, Amasino RM. Acceleration of flowering during shade avoidance in Arabidopsis alters the balance between FLOWERING LOCUS C-mediated repression and photoperiodic induction of flowering. Plant Physiol. 2008 Nov;148(3):1681-94. PMID:18790998 doi:10.1104/pp.108.125468
4. ↑ Kidd BN, Edgar CI, Kumar KK, Aitken EA, Schenk PM, Manners JM, Kazan K. The mediator complex subunit PFT1 is a key regulator of jasmonate-dependent defense in Arabidopsis. Plant Cell. 2009 Aug;21(8):2237-52. PMID:19671879 doi:10.1105/tpc.109.066910
5. ↑ Elfving N, Davoine C, Benlloch R, Blomberg J, Brännström K, Müller D, Nilsson A, Ulfstedt M, Ronne H, Wingsle G, Nilsson O, Björklund S. The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8245-50. PMID:21536906 doi:10.1073/pnas.1002981108
6. ↑ Iñigo S, Alvarez MJ, Strasser B, Califano A, Cerdán PD. PFT1, the MED25 subunit of the plant Mediator complex, promotes flowering through CONSTANS dependent and independent mechanisms in Arabidopsis. Plant J. 2012 Feb;69(4):601-12. PMID:21985558 doi:10.1111/j.1365-313X.2011.04815.x