Structural highlights
Function
SBI_STAAM Plays a role in the inhibition of both the innate and adaptive immune responses. Possesses two N-terminal domains that bind the Fc region of IgG and two domains that form a tripartite complex with complement factors C3b and CFH. By recruiting CFH and C3b, the secreted form acts as a potent complement inhibitor of the alternative pathway-mediated lysis.[UniProtKB:A6QJQ7][1]
References
- ↑ Upadhyay A, Burman JD, Clark EA, Leung E, Isenman DE, van den Elsen JM, Bagby S. Structure-function analysis of the C3 binding region of Staphylococcus aureus immune subversion protein Sbi. J Biol Chem. 2008 Aug 8;283(32):22113-20. Epub 2008 Jun 11. PMID:18550524 doi:10.1074/jbc.M802636200
