2km1

Structural highlights

Function

DRE2_YEAST Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein TAH18. Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death.[HAMAP-Rule:MF_03115]^{[1] [2] [3] [4] [5]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Chanet R, Heude M. Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae. Curr Genet. 2003 Aug;43(5):337-50. Epub 2003 May 21. PMID:12759774 doi:http://dx.doi.org/10.1007/s00294-003-0407-2
2. ↑ Zhang Y, Lyver ER, Nakamaru-Ogiso E, Yoon H, Amutha B, Lee DW, Bi E, Ohnishi T, Daldal F, Pain D, Dancis A. Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis. Mol Cell Biol. 2008 Sep;28(18):5569-82. doi: 10.1128/MCB.00642-08. Epub 2008 Jul , 14. PMID:18625724 doi:http://dx.doi.org/10.1128/MCB.00642-08
3. ↑ Vernis L, Facca C, Delagoutte E, Soler N, Chanet R, Guiard B, Faye G, Baldacci G. A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast. PLoS One. 2009;4(2):e4376. doi: 10.1371/journal.pone.0004376. Epub 2009 Feb 5. PMID:19194512 doi:http://dx.doi.org/10.1371/journal.pone.0004376
4. ↑ Netz DJ, Stumpfig M, Dore C, Muhlenhoff U, Pierik AJ, Lill R. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol. 2010 Oct;6(10):758-65. doi: 10.1038/nchembio.432. Epub 2010 Aug, 29. PMID:20802492 doi:http://dx.doi.org/10.1038/nchembio.432
5. ↑ Soler N, Delagoutte E, Miron S, Facca C, Baille D, d'Autreaux B, Craescu G, Frapart YM, Mansuy D, Baldacci G, Huang ME, Vernis L. Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability. Mol Microbiol. 2011 Oct;82(1):54-67. doi: 10.1111/j.1365-2958.2011.07788.x. Epub , 2011 Sep 8. PMID:21902732 doi:http://dx.doi.org/10.1111/j.1365-2958.2011.07788.x