2mh2

Structural highlights

Function

HOP2_MOUSE Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.^{[1] [2] [3] [4] [5] [6]}

References

1. ↑ Tanaka T, Nakamura T, Takagi H, Sato M. Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP. Biochem Biophys Res Commun. 1997 Oct 9;239(1):176-81. PMID:9345291 doi:http://dx.doi.org/10.1006/bbrc.1997.7447
2. ↑ Enomoto R, Kinebuchi T, Sato M, Yagi H, Shibata T, Kurumizaka H, Yokoyama S. Positive role of the mammalian TBPIP/HOP2 protein in DMC1-mediated homologous pairing. J Biol Chem. 2004 Aug 20;279(34):35263-72. Epub 2004 Jun 10. PMID:15192114 doi:http://dx.doi.org/10.1074/jbc.M402481200
3. ↑ Pezza RJ, Petukhova GV, Ghirlando R, Camerini-Otero RD. Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex. J Biol Chem. 2006 Jul 7;281(27):18426-34. Epub 2006 May 4. PMID:16675459 doi:http://dx.doi.org/M601073200
4. ↑ Chi P, San Filippo J, Sehorn MG, Petukhova GV, Sung P. Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase. Genes Dev. 2007 Jul 15;21(14):1747-57. PMID:17639080 doi:http://dx.doi.org/21/14/1747
5. ↑ Pezza RJ, Voloshin ON, Vanevski F, Camerini-Otero RD. Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing. Genes Dev. 2007 Jul 15;21(14):1758-66. PMID:17639081 doi:http://dx.doi.org/21/14/1758
6. ↑ Ploquin M, Petukhova GV, Morneau D, Dery U, Bransi A, Stasiak A, Camerini-Otero RD, Masson JY. Stimulation of fission yeast and mouse Hop2-Mnd1 of the Dmc1 and Rad51 recombinases. Nucleic Acids Res. 2007;35(8):2719-33. Epub 2007 Apr 10. PMID:17426123 doi:http://dx.doi.org/gkm174