2pa1
From Proteopedia
Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin
Structural highlights
FunctionPDLI2_HUMAN Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. Evolutionary ConservationCheck, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bunkoczi G | Burgess-Brown N | Doyle DA | Edwards A | Elkins J | Papagrigoriou E | Pike ACW | Salah E | Shrestha L | Sundstrom M | Turnbull AP | Ugochukwu E | Umeano C | Uppenberg J | Weigelt J | Von Delft F