Structural highlights
Function
5BPOR_DIGLA Involved in cardenolide biosynthesis. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 4-androstene-3,17-dione, cortisol and cortisone as substrates, but not pregnenolone, 21-OH-pregnenolone or isoprogesterone. NADPH could not be replaced by NADH.[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Herl V, Fischer G, Muller-Uri F, Kreis W. Molecular cloning and heterologous expression of progesterone 5beta-reductase from Digitalis lanata Ehrh. Phytochemistry. 2006 Feb;67(3):225-31. Epub 2005 Dec 28. PMID:16386278 doi:http://dx.doi.org/10.1016/j.phytochem.2005.11.013
- ↑ Thorn A, Egerer-Sieber C, Jager CM, Herl V, Muller-Uri F, Kreis W, Muller YA. The crystal structure of progesterone 5beta-reductase from Digitalis lanata defines a novel class of short chain dehydrogenases/reductases. J Biol Chem. 2008 Jun 20;283(25):17260-9. Epub 2007 Nov 21. PMID:18032383 doi:10.1074/jbc.M706185200
