3ano

Structural highlights

Function

AP4A_MYCTU Catabolizes diadenosine 5',5-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.^{[1] [2]}

References

1. ↑ Mori S, Shibayama K, Wachino J, Arakawa Y. Purification and molecular characterization of a novel diadenosine 5',5-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv. Protein Expr Purif. 2010 Jan;69(1):99-105. doi: 10.1016/j.pep.2009.09.010. Epub, 2009 Sep 22. PMID:19778616 doi:http://dx.doi.org/10.1016/j.pep.2009.09.010
2. ↑ Mori S, Shibayama K, Wachino J, Arakawa Y. Structural insights into the novel diadenosine 5',5-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv. J Mol Biol. 2011 Jul 1;410(1):93-104. doi: 10.1016/j.jmb.2011.04.059. Epub 2011, May 4. PMID:21565198 doi:http://dx.doi.org/10.1016/j.jmb.2011.04.059