3ja7

Structural highlights

Function

PORTL_BPT4 Forms the portal vertex of the capsid (PubMed:2685327, PubMed:24126213). This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection. The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel. Binds to the terminase subunits to form the packaging machine. Attaches to the host inner membrane most likely through interaction with host yidC and forms together with chaperone gp40 an initiator complex to form the prohead.^{[1] [2]}

See Also

• Portal protein 3D structures

References

1. ↑ Padilla-Sanchez V, Gao S, Kim HR, Kihara D, Sun L, Rossmann MG, Rao VB. Structure-function analysis of the DNA translocating portal of the bacteriophage T4 packaging machine. J Mol Biol. 2014 Mar 6;426(5):1019-38. doi: 10.1016/j.jmb.2013.10.011. Epub 2013 , Oct 11. PMID:24126213 doi:http://dx.doi.org/10.1016/j.jmb.2013.10.011
2. ↑ Michaud G, Zachary A, Rao VB, Black LW. Membrane-associated assembly of a phage T4 DNA entrance vertex structure studied with expression vectors. J Mol Biol. 1989 Oct 20;209(4):667-81. PMID:2685327 doi:http://dx.doi.org/10.1016/0022-2836(89)90599-8