3nug
From Proteopedia
Crystal structure of wild type tetrameric pyridoxal 4-dehydrogenase from Mesorhizobium loti
Structural highlights
FunctionPLDH_RHILO Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Oxidizes pyridoxal to 4-pyridoxolactone, but does not have activity toward pyridoxal 5'-phosphate, pyridoxine, pyridoxamine, pyridoxamine 5'-phosphate, 4-phthalaldehyde, 2-nitrobenzaldehyde, pyridine, formaldehyde, 2-carboxybenzaldehyde or sugars.[1] Publication Abstract from PubMedPyridoxal 4-dehydrogenase catalyzes the irreversible oxidation of pyridoxal to 4-pyridoxolactone and is involved in degradation pathway I of pyridoxine, a vitamin B(6) compound. Its crystal structure was elucidated for the first time. Molecular replacement with (S)-1-phenylthanol dehydrogenase (PDB code 2EW8) was adopted to determine the tertiary structure of the NAD(+)-bound enzyme. The crystal structure of SDR-type pyridoxal 4-dehydrogenase of Mesorhizobium loti.,Chu HN, Kobayashi J, Mikami B, Yagi T Biosci Biotechnol Biochem. 2011;75(2):388-90. Epub 2011 Feb 7. PMID:21307574[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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