3rq9

Structural highlights

Function

TSI2_PSEAE Immunity protein that plays a role in preventing early activation of toxin Tse2. Binds to a large surface of Tse2 and thereby occludes the active site to specifically inhibits Tse2.^{[1] [2] [3]}

References

1. ↑ Zou T, Yao X, Qin B, Zhang M, Cai L, Shang W, Svergun DI, Wang M, Cui S, Jin Q. Crystal structure of Pseudomonas aeruginosa Tsi2 reveals a stably folded superhelical antitoxin. J Mol Biol. 2012 Apr 6;417(4):351-61. Epub 2012 Jan 30. PMID:22310046 doi:10.1016/j.jmb.2012.01.040
2. ↑ Li M, Le Trong I, Carl MA, Larson ET, Chou S, De Leon JA, Dove SL, Stenkamp RE, Mougous JD. Structural Basis for Type VI Secretion Effector Recognition by a Cognate Immunity Protein. PLoS Pathog. 2012 Apr;8(4):e1002613. Epub 2012 Apr 12. PMID:22511866 doi:10.1371/journal.ppat.1002613
3. ↑ Robb CS, Robb M, Nano FE, Boraston AB. The Structure of the Toxin and Type Six Secretion System Substrate Tse2 in Complex with Its Immunity Protein. Structure. 2015 Dec 28. pii: S0969-2126(15)00501-8. doi:, 10.1016/j.str.2015.11.012. PMID:26749446 doi:http://dx.doi.org/10.1016/j.str.2015.11.012