3s60

Structural highlights

Function

LEC1_PLAAG Lectin specific for high mannose N-glycans, recognizes the branched moiety of these glycans. Does not recognize other types of N-glycans or monosaccharides. Agglutinates trypsin-treated rabbit erythrocytes. Does not require divalent cations for activity. Inhibits HIV replication in MT4 cells with an EC(50) of 45 nM. Binds to the HIV envelope glycoprotein gp120.^{[1] [2]}

See Also

• Agglutinin 3D structures

References

1. ↑ Sato Y, Murakami M, Miyazawa K, Hori K. Purification and characterization of a novel lectin from a freshwater cyanobacterium, Oscillatoria agardhii. Comp Biochem Physiol B Biochem Mol Biol. 2000 Feb;125(2):169-77. PMID:10817903 doi:10.1016/s0305-0491(99)00164-9
2. ↑ Sato Y, Okuyama S, Hori K. Primary structure and carbohydrate binding specificity of a potent anti-HIV lectin isolated from the filamentous cyanobacterium Oscillatoria agardhii. J Biol Chem. 2007 Apr 13;282(15):11021-9. Epub 2007 Feb 21. PMID:17314091 doi:10.1074/jbc.M701252200