3s6b

Structural highlights

Function

MAP1B_PLAF7 Cotranslationally removes the N-terminal methionine from nascent proteins (PubMed:16983082, PubMed:27023914). The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) (By similarity). May play an important role in parasite growth during the blood asexual stage (PubMed:16983082).[HAMAP-Rule:MF_03174]^{[1] [2]}

See Also

• Aminopeptidase 3D structures

References

1. ↑ Chen X, Chong CR, Shi L, Yoshimoto T, Sullivan DJ Jr, Liu JO. Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14548-53. PMID:16983082 doi:10.1073/pnas.0604101103
2. ↑ Calcagno S, Klein CD. N-Terminal methionine processing by the zinc-activated Plasmodium falciparum methionine aminopeptidase 1b. Appl Microbiol Biotechnol. 2016 Aug;100(16):7091-102. PMID:27023914 doi:10.1007/s00253-016-7470-3