Structural highlights
Function
DINJ_ECOBD Antitoxin component of a type II toxin-antitoxin (TA) system (PubMed:24923448). A labile antitoxin that counteracts the effect of cognate toxin YafQ (PubMed:24923448). The YafQ-DinJ heterotetramer binds the consensus sequence 5'-TTTGAGCTACA-3' in the dinJ promoter; DinJ also binds DNA but not as well as the YafQ-DinJ complex (PubMed:24923448). Binding to the dinJ represses expression of the promoter (By similarity).[UniProtKB:Q47150][1]
References
- ↑ Liang Y, Gao Z, Wang F, Zhang Y, Dong Y, Liu Q. Structural and Functional Characterization of Escherichia coli Toxin-antitoxin Complex DinJ-YafQ. J Biol Chem. 2014 Jun 12. pii: jbc.M114.559773. PMID:24923448 doi:http://dx.doi.org/10.1074/jbc.M114.559773
