Structural highlights
Function
DI3L2_SCHPO 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.[HAMAP-Rule:MF_03045][1]
References
- ↑ Malecki M, Viegas SC, Carneiro T, Golik P, Dressaire C, Ferreira MG, Arraiano CM. The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway. EMBO J. 2013 Jul 3;32(13):1842-54. doi: 10.1038/emboj.2013.63. Epub 2013 Mar 15. PMID:23503588 doi:http://dx.doi.org/10.1038/emboj.2013.63
