5g49

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Crystal structure of the Arabodopsis thaliana histone-fold dimer L1L NF-YC3

Structural highlights

5g49 is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:ACT, CA
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NFYB6_ARATH Component of the NF-Y/HAP transcription factor complex. The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters. Plays a role in the regulation of the embryogenesis. Involved in the abscisic acid (ABA) signaling pathway.[1] [2]

Publication Abstract from PubMed

The structural analysis of the L1L/NF-YC3 histone dimer from A. thaliana shows that it can trimerize and bind to the CCAAT box. Specific sequence and structural features at the protein/DNA interface, in particular the presence of a Asp-His pair, help explain the molecular mechanisms of LEC1/L1L activity as a bona fide mammalian-like NF-YB.

Crystal structure of the Arabidopsis thaliana L1L/NF-YC3 histone-fold dimer reveals specificities of the LEC1 family of NF-Y subunits in plants.,Gnesutta N, Saad D, Chaves-Sanjuan A, Mantovani R, Nardini M Mol Plant. 2016 Nov 18. pii: S1674-2052(16)30276-3. doi:, 10.1016/j.molp.2016.11.006. PMID:27871811[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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See Also

References

  1. ↑ Kwong RW, Bui AQ, Lee H, Kwong LW, Fischer RL, Goldberg RB, Harada JJ. LEAFY COTYLEDON1-LIKE defines a class of regulators essential for embryo development. Plant Cell. 2003 Jan;15(1):5-18. PMID:12509518
  2. ↑ Warpeha KM, Upadhyay S, Yeh J, Adamiak J, Hawkins SI, Lapik YR, Anderson MB, Kaufman LS. The GCR1, GPA1, PRN1, NF-Y signal chain mediates both blue light and abscisic acid responses in Arabidopsis. Plant Physiol. 2007 Apr;143(4):1590-600. Epub 2007 Feb 23. PMID:17322342 doi:http://dx.doi.org/10.1104/pp.106.089904
  3. ↑ Gnesutta N, Saad D, Chaves-Sanjuan A, Mantovani R, Nardini M. Crystal structure of the Arabidopsis thaliana L1L/NF-YC3 histone-fold dimer reveals specificities of the LEC1 family of NF-Y subunits in plants. Mol Plant. 2016 Nov 18. pii: S1674-2052(16)30276-3. doi:, 10.1016/j.molp.2016.11.006. PMID:27871811 doi:http://dx.doi.org/10.1016/j.molp.2016.11.006

Contents


PDB ID 5g49

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