5msq

Structural highlights

Function

CAR_NOCIO Catalyzes the reduction of a very wide range of aliphatic carboxylic acids as well as many aryl carboxylic acids into their corresponding aldehydes, by using ATP for energy to drive the reaction. Aryl carboxylic acid substrates include substituted benzoic acids, phenyl-substituted aliphatic acids, heterocyclic carboxylic acids, and polyaromatic ring carboxylic acids. Cannot reduce benzaldehyde to benzyl alcohol.^{[1] [2] [3] [4]}

References

1. ↑ He A, Li T, Daniels L, Fotheringham I, Rosazza JP. Nocardia sp. carboxylic acid reductase: cloning, expression, and characterization of a new aldehyde oxidoreductase family. Appl Environ Microbiol. 2004 Mar;70(3):1874-81. PMID:15006821
2. ↑ Venkitasubramanian P, Daniels L, Rosazza JP. Reduction of carboxylic acids by Nocardia aldehyde oxidoreductase requires a phosphopantetheinylated enzyme. J Biol Chem. 2007 Jan 5;282(1):478-85. Epub 2006 Nov 13. PMID:17102130 doi:http://dx.doi.org/10.1074/jbc.M607980200
3. ↑ Li T, Rosazza JP. Purification, characterization, and properties of an aryl aldehyde oxidoreductase from Nocardia sp. strain NRRL 5646. J Bacteriol. 1997 Jun;179(11):3482-7. PMID:9171390
4. ↑ Li T, Rosazza JP. Purification, characterization, and properties of an aryl aldehyde oxidoreductase from Nocardia sp. strain NRRL 5646. J Bacteriol. 1997 Jun;179(11):3482-7. PMID:9171390