5nqs

Structural highlights

Function

TPL_ARATH Transcriptional corepressor. May repress the expression of root-promoting genes in the top half of the embryo to allow proper differentiation of the shoot pole during the transition stage of embryogenesis. Regulates the expression of PLT1 and PLT2. Negative regulator of jasmonate responses. Negative regulator of auxin responses. Negative regulator of multiple floral organ identity genes (PubMed:23034631). Required for ovule development (PubMed:25378179).^{[1] [2] [3] [4] [5] [6]}

References

1. ↑ Long JA, Ohno C, Smith ZR, Meyerowitz EM. TOPLESS regulates apical embryonic fate in Arabidopsis. Science. 2006 Jun 9;312(5779):1520-3. PMID:16763149 doi:http://dx.doi.org/10.1126/science.1123841
2. ↑ Szemenyei H, Hannon M, Long JA. TOPLESS mediates auxin-dependent transcriptional repression during Arabidopsis embryogenesis. Science. 2008 Mar 7;319(5868):1384-6. doi: 10.1126/science.1151461. Epub 2008 Feb, 7. PMID:18258861 doi:http://dx.doi.org/10.1126/science.1151461
3. ↑ Smith ZR, Long JA. Control of Arabidopsis apical-basal embryo polarity by antagonistic transcription factors. Nature. 2010 Mar 18;464(7287):423-6. doi: 10.1038/nature08843. Epub 2010 Feb 28. PMID:20190735 doi:http://dx.doi.org/10.1038/nature08843
4. ↑ Pauwels L, Barbero GF, Geerinck J, Tilleman S, Grunewald W, Perez AC, Chico JM, Bossche RV, Sewell J, Gil E, Garcia-Casado G, Witters E, Inze D, Long JA, De Jaeger G, Solano R, Goossens A. NINJA connects the co-repressor TOPLESS to jasmonate signalling. Nature. 2010 Apr 1;464(7289):788-91. doi: 10.1038/nature08854. PMID:20360743 doi:http://dx.doi.org/10.1038/nature08854
5. ↑ Krogan NT, Hogan K, Long JA. APETALA2 negatively regulates multiple floral organ identity genes in Arabidopsis by recruiting the co-repressor TOPLESS and the histone deacetylase HDA19. Development. 2012 Nov;139(22):4180-90. doi: 10.1242/dev.085407. Epub 2012 Oct 3. PMID:23034631 doi:http://dx.doi.org/10.1242/dev.085407
6. ↑ Wei B, Zhang J, Pang C, Yu H, Guo D, Jiang H, Ding M, Chen Z, Tao Q, Gu H, Qu LJ, Qin G. The molecular mechanism of sporocyteless/nozzle in controlling Arabidopsis ovule development. Cell Res. 2015 Jan;25(1):121-34. doi: 10.1038/cr.2014.145. Epub 2014 Nov 7. PMID:25378179 doi:http://dx.doi.org/10.1038/cr.2014.145