5y37
From Proteopedia
Crystal structure of GBS GAPDH
Structural highlights
FunctionPublication Abstract from PubMedGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional enzyme that plays critical roles in bacterial pathogenesis in some pathogenic bacteria. In this study, the crystal structure of group B streptococcus GAPDH was determined at 1.36 A resolution. The structure contained an asymmetric mixed holo tetramer, with two NAD ligands bound to two protomers. Further structural analysis identified interesting phosphate ion-binding sites, which shed light on its catalytic mechanism. High-resolution crystal structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase.,Zhou K, Fan X, Li Y, Zhang C, Jin T Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):236-244. doi:, 10.1107/S2053230X18003801. Epub 2018 Mar 23. PMID:29633972[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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