5ykj

Structural highlights

Function

PRX1_YEAST Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Involved in mitochondrial protection of cadmium-induced oxidative stress.^{[1] [2] [3]}

See Also

• Peroxiredoxin 3D structures

References

1. ↑ Pedrajas JR, Miranda-Vizuete A, Javanmardy N, Gustafsson JA, Spyrou G. Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity. J Biol Chem. 2000 May 26;275(21):16296-301. PMID:10821871
2. ↑ Greetham D, Grant CM. Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo. Mol Cell Biol. 2009 Jun;29(11):3229-40. doi: 10.1128/MCB.01918-08. Epub 2009 Mar , 30. PMID:19332553 doi:http://dx.doi.org/10.1128/MCB.01918-08
3. ↑ Pedrajas JR, Padilla CA, McDonagh B, Barcena JA. Glutaredoxin participates in the reduction of peroxides by the mitochondrial 1-CYS peroxiredoxin in Saccharomyces cerevisiae. Antioxid Redox Signal. 2010 Aug 1;13(3):249-58. doi: 10.1089/ars.2009.2950. PMID:20059400 doi:http://dx.doi.org/10.1089/ars.2009.2950