Structural highlights
6jbd is a 1 chain structure with sequence from Thermococcus kodakarensis KOD1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.5Å |
| Ligands: | , , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
POK_THEKO Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway (PubMed:19666462, PubMed:22865846). Displays broad nucleotide specificity and utilizes ATP, GTP, UTP, and CTP with comparable catalytic efficiencies (PubMed:22865846).[1] [2]
References
- ↑ Yokooji Y, Tomita H, Atomi H, Imanaka T. Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea. J Biol Chem. 2009 Oct 9;284(41):28137-45. doi: 10.1074/jbc.M109.009696. Epub 2009, Aug 7. PMID:19666462 doi:http://dx.doi.org/10.1074/jbc.M109.009696
- ↑ Tomita H, Yokooji Y, Ishibashi T, Imanaka T, Atomi H. Biochemical characterization of pantoate kinase, a novel enzyme necessary for coenzyme A biosynthesis in the Archaea. J Bacteriol. 2012 Oct;194(19):5434-43. doi: 10.1128/JB.06624-11. Epub 2012 Aug 3. PMID:22865846 doi:http://dx.doi.org/10.1128/JB.06624-11
