6lvh

Structural highlights

Function

MAP2_PYRFU Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).[HAMAP-Rule:MF_01975]^[1]

See Also

• Aminopeptidase 3D structures

References

1. ↑ Tsunasawa S, Izu Y, Miyagi M, Kato I. Methionine aminopeptidase from the hyperthermophilic Archaeon Pyrococcus furiosus: molecular cloning and overexpression in Escherichia coli of the gene, and characteristics of the enzyme. J Biochem. 1997 Oct;122(4):843-50. PMID:9399590 doi:10.1093/oxfordjournals.jbchem.a021831