Structural highlights
Function
TFE_PYRFU Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.[1] [2]
References
- ↑ Grunberg S, Bartlett MS, Naji S, Thomm M. Transcription factor E is a part of transcription elongation complexes. J Biol Chem. 2007 Dec 7;282(49):35482-90. doi: 10.1074/jbc.M707371200. Epub 2007 , Oct 5. PMID:17921145 doi:http://dx.doi.org/10.1074/jbc.M707371200
- ↑ Micorescu M, Grunberg S, Franke A, Cramer P, Thomm M, Bartlett M. Archaeal transcription: function of an alternative transcription factor B from Pyrococcus furiosus. J Bacteriol. 2008 Jan;190(1):157-67. doi: 10.1128/JB.01498-07. Epub 2007 Oct 26. PMID:17965161 doi:http://dx.doi.org/10.1128/JB.01498-07
