6wg7

Structural highlights

Function

NANR_ECOLI Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids (PubMed:9864311, PubMed:12897000, PubMed:23935044). Represses expression of the nanATEK-yhcH, nanCMS and yjhBC operons. Acts by binding directly to the Nan box, a region of approximately 30 bp covering the promoter region (PubMed:23935044).^{[1] [2] [3]}

References

1. ↑ Kalivoda KA, Steenbergen SM, Vimr ER, Plumbridge J. Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli. J Bacteriol. 2003 Aug;185(16):4806-15. PMID:12897000 doi:10.1128/JB.185.16.4806-4815.2003
2. ↑ Kalivoda KA, Steenbergen SM, Vimr ER. Control of the Escherichia coli sialoregulon by transcriptional repressor NanR. J Bacteriol. 2013 Oct;195(20):4689-701. PMID:23935044 doi:10.1128/JB.00692-13
3. ↑ Plumbridge J, Vimr E. Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli. J Bacteriol. 1999 Jan;181(1):47-54. PMID:9864311