7dta

Structural highlights

Function

S2A4R_HUMAN Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'.^{[1] [2]}

References

1. ↑ Tanaka K, Shouguchi-Miyata J, Miyamoto N, Ikeda JE. Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene. J Biol Chem. 2004 Feb 20;279(8):7275-86. PMID:14625278 doi:10.1074/jbc.M310726200
2. ↑ Knight JB, Eyster CA, Griesel BA, Olson AL. Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14725-30. PMID:14630949 doi:10.1073/pnas.2432756100