Structural highlights
Publication Abstract from PubMed
Human ATP-binding cassette transporter 8 of subfamily B (hABCB8) is an ABC transporter that located in the inner membrane of mitochondria. The ABCB8 is involved in the maturation of Fe-S and protects the heart from oxidative stress. Here, we present the cryo-EM structure of human ABCB8 binding with AMPPNP in inward-facing conformation with resolution of 4.1 A. hABCB8 shows an open-inward conformation when ATP is bound. Unexpectedly, cholesterol molecules were identified in the transmembrane domain of hABCB8. Our results provide structural basis for the transport mechanism of the ABC transporter in mitochondria.
Cryo-EM structure of human ABCB8 transporter in nucleotide binding state.,Li S, Ren Y, Lu X, Shen Y, Yang X Biochem Biophys Res Commun. 2021 Apr 16;557:187-191. doi:, 10.1016/j.bbrc.2021.04.007. PMID:33872987[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Li S, Ren Y, Lu X, Shen Y, Yang X. Cryo-EM structure of human ABCB8 transporter in nucleotide binding state. Biochem Biophys Res Commun. 2021 Jun 11;557:187-191. PMID:33872987 doi:10.1016/j.bbrc.2021.04.007
