Structural highlights
7jh0 is a 4 chain structure with sequence from Schistosoma mansoni. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.51Å |
| Ligands: | , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
G3P_SCHMA This antigen is associated with human resistance to schistosomiasis.
Publication Abstract from PubMed
The enzyme Glyceraldehyde-3-Phosphate Dehydrogenase from Schistosoma mansoni (SmGAPDH) is characterized as a therapeutical target for schistosomiasis. In this context, we report here the experimental structure, structural analyses and comparisons of SmGAPDH, the first one from a Platyhelminth. The enzyme was expressed, purified and assayed for crystallization, what allowed the obtainment of crystals of sufficient quality to collect X-ray diffraction data up to 2.51 A resolution. SmGAPDH is the only GAPDH to present the sequence NNR (its residues 114-116) which leads to (especially R116) a hydrogen bond network that possibly reflects on the flexibility of residues to interact with the adenine part of NAD(+), speculated to be important for differential drug design.
Structure determination and analyses of the GAPDH from the parasite Schistosoma mansoni, the first one from a platyhelminth.,Boreiko S, Silva M, Iulek J Biochimie. 2021 May;184:18-25. doi: 10.1016/j.biochi.2021.01.014. Epub 2021 Jan , 30. PMID:33524435[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Boreiko S, Silva M, Iulek J. Structure determination and analyses of the GAPDH from the parasite Schistosoma mansoni, the first one from a platyhelminth. Biochimie. 2021 May;184:18-25. PMID:33524435 doi:10.1016/j.biochi.2021.01.014
