Structural highlights
Publication Abstract from PubMed
SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 A-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome, and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics.
Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot.,Jones CP, Ferre-D'Amare AR RNA. 2021 Nov 29. pii: rna.078825.121. doi: 10.1261/rna.078825.121. PMID:34845084[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Jones CP, Ferre-D'Amare AR. Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot. RNA. 2021 Nov 29. pii: rna.078825.121. doi: 10.1261/rna.078825.121. PMID:34845084 doi:http://dx.doi.org/10.1261/rna.078825.121
