Structural highlights
Function
VFLIP_HHV8P Plays a role in the modulation of host signaling pathways by acting as an activator of both the classic and the alternative NF-kappa-B pathways. Thereby, initiates an important range of cellular processes to promote cell survival, proliferation and protection from apoptosis.[1] [2] [3]
References
- ↑ Chaudhary PM, Jasmin A, Eby MT, Hood L. Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins. Oncogene. 1999 Oct 14;18(42):5738-46. PMID:10523854 doi:10.1038/sj.onc.1202976
- ↑ Guasparri I, Wu H, Cesarman E. The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signalling. EMBO Rep. 2006 Jan;7(1):114-9. PMID:16311516 doi:10.1038/sj.embor.7400580
- ↑ Hunte R, Alonso P, Thomas R, Bazile CA, Ramos JC, van der Weyden L, Dominguez-Bendala J, Khan WN, Shembade N. CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation. PLoS Pathog. 2018 Apr 26;14(4):e1006968. PMID:29698475 doi:10.1371/journal.ppat.1006968
