7pmx

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HsPepT1 bound to Ala-Phe in the outward facing open conformation

Structural highlights

7pmx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

S15A1_HUMAN Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7896779, PubMed:18367661, PubMed:19685173). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity).[UniProtKB:P36836][1] [2] [3]

Publication Abstract from PubMed

[Figure: see text].

Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.,Killer M, Wald J, Pieprzyk J, Marlovits TC, Low C Sci Adv. 2021 Nov 5;7(45):eabk3259. doi: 10.1126/sciadv.abk3259. Epub 2021 Nov 3. PMID:34730990[4]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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References

  1. ↑ Sala-Rabanal M, Loo DD, Hirayama BA, Wright EM. Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2. Am J Physiol Renal Physiol. 2008 Jun;294(6):F1422-32. doi:, 10.1152/ajprenal.00030.2008. Epub 2008 Mar 26. PMID:18367661 doi:http://dx.doi.org/10.1152/ajprenal.00030.2008
  2. ↑ Xu L, Haworth IS, Kulkarni AA, Bolger MB, Davies DL. Mutagenesis and cysteine scanning of transmembrane domain 10 of the human dipeptide transporter. Pharm Res. 2009 Oct;26(10):2358-66. doi: 10.1007/s11095-009-9952-9. Epub 2009 Aug, 14. PMID:19685173 doi:http://dx.doi.org/10.1007/s11095-009-9952-9
  3. ↑ Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH. Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem. 1995 Mar 24;270(12):6456-63. doi: 10.1074/jbc.270.12.6456. PMID:7896779 doi:http://dx.doi.org/10.1074/jbc.270.12.6456
  4. ↑ Killer M, Wald J, Pieprzyk J, Marlovits TC, Low C. Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes. Sci Adv. 2021 Nov 5;7(45):eabk3259. doi: 10.1126/sciadv.abk3259. Epub 2021 Nov 3. PMID:34730990 doi:http://dx.doi.org/10.1126/sciadv.abk3259

Contents


PDB ID 7pmx

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OCA

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