Structural highlights
Function
APYC1_BPBSP Counteracts the host Pycsar antiviral defense system. Phosphodiesterase that enables metal-dependent hydrolysis of host cyclic nucleotide Pycsar defense signals such as cCMP and cUMP.[1]
References
- ↑ Hobbs SJ, Wein T, Lu A, Morehouse BR, Schnabel J, Leavitt A, Yirmiya E, Sorek R, Kranzusch PJ. Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Nature. 2022 May;605(7910):522-526. PMID:35395152 doi:10.1038/s41586-022-04716-y