7t7i

Structural highlights

Function

NEC2_EBVB9 Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.[HAMAP-Rule:MF_04024]^{[1] [2]}

References

1. ↑ Farina A, Feederle R, Raffa S, Gonnella R, Santarelli R, Frati L, Angeloni A, Torrisi MR, Faggioni A, Delecluse HJ. BFRF1 of Epstein-Barr virus is essential for efficient primary viral envelopment and egress. J Virol. 2005 Mar;79(6):3703-12. doi: 10.1128/JVI.79.6.3703-3712.2005. PMID:15731264 doi:http://dx.doi.org/10.1128/JVI.79.6.3703-3712.2005
2. ↑ Granato M, Farina A, Gonnella R, Santarelli R, Frati L, Faggioni A, Angeloni A. Regulation of the expression of the Epstein-Barr virus early gene BFRF1. Virology. 2006 Mar 30;347(1):109-16. doi: 10.1016/j.virol.2005.11.046. Epub 2006 , Jan 9. PMID:16406456 doi:http://dx.doi.org/10.1016/j.virol.2005.11.046