Structural highlights
Function
SETB1_DROME Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 in ovary. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis.[1]
References
- ↑ Clough E, Moon W, Wang S, Smith K, Hazelrigg T. Histone methylation is required for oogenesis in Drosophila. Development. 2007 Jan;134(1):157-65. PMID:17164421 doi:10.1242/dev.02698
