| Structural highlights
Function
ECCA5_MYCTU Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41 (PubMed:22340629, PubMed:22925462). EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity).[UniProtKB:P9WPH9][1] [2]
References
- ↑ Bottai D, Di Luca M, Majlessi L, Frigui W, Simeone R, Sayes F, Bitter W, Brennan MJ, Leclerc C, Batoni G, Campa M, Brosch R, Esin S. Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation. Mol Microbiol. 2012 Mar;83(6):1195-209. doi: 10.1111/j.1365-2958.2012.08001.x., Epub 2012 Feb 20. PMID:22340629 doi:http://dx.doi.org/10.1111/j.1365-2958.2012.08001.x
- ↑ Houben EN, Bestebroer J, Ummels R, Wilson L, Piersma SR, Jimenez CR, Ottenhoff TH, Luirink J, Bitter W. Composition of the type VII secretion system membrane complex. Mol Microbiol. 2012 Oct;86(2):472-84. doi: 10.1111/j.1365-2958.2012.08206.x. Epub, 2012 Aug 27. PMID:22925462 doi:http://dx.doi.org/10.1111/j.1365-2958.2012.08206.x
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