Structural highlights
Disease
SHAN2_HUMAN NON RARE IN EUROPE: Autism. Disease susceptibility is associated with variants affecting the gene represented in this entry.
Function
SHAN2_HUMAN Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
