8bnr

Structural highlights

Function

FADI_ECOLI Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long-chain fatty acids.^{[1] [2]}

References

1. ↑ Snell KD, Feng F, Zhong L, Martin D, Madison LL. YfcX enables medium-chain-length poly(3-hydroxyalkanoate) formation from fatty acids in recombinant Escherichia coli fadB strains. J Bacteriol. 2002 Oct;184(20):5696-705. PMID:12270828 doi:10.1128/JB.184.20.5696-5705.2002
2. ↑ Campbell JW, Morgan-Kiss RM, Cronan JE Jr. A new Escherichia coli metabolic competency: growth on fatty acids by a novel anaerobic beta-oxidation pathway. Mol Microbiol. 2003 Feb;47(3):793-805. doi: 10.1046/j.1365-2958.2003.03341.x. PMID:12535077 doi:http://dx.doi.org/10.1046/j.1365-2958.2003.03341.x