8ec6

Structural highlights

Function

GLSK_MOUSE Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain.^{[1] [2] [3]}

References

1. ↑ Masson J, Darmon M, Conjard A, Chuhma N, Ropert N, Thoby-Brisson M, Foutz AS, Parrot S, Miller GM, Jorisch R, Polan J, Hamon M, Hen R, Rayport S. Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth. J Neurosci. 2006 Apr 26;26(17):4660-71. PMID:16641247 doi:10.1523/JNEUROSCI.4241-05.2006
2. ↑ El Hage M, Masson J, Conjard-Duplany A, Ferrier B, Baverel G, Martin G. Brain slices from glutaminase-deficient mice metabolize less glutamine: a cellular metabolomic study with carbon 13 NMR. J Cereb Blood Flow Metab. 2012 May;32(5):816-24. doi: 10.1038/jcbfm.2012.22. Epub, 2012 Feb 29. PMID:22373647 doi:10.1038/jcbfm.2012.22
3. ↑ Cassago A, Ferreira AP, Ferreira IM, Fornezari C, Gomes ER, Greene KS, Pereira HM, Garratt RC, Dias SM, Ambrosio AL. Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1092-7. Epub 2012 Jan 6. PMID:22228304 doi:10.1073/pnas.1112495109