8gsc
From Proteopedia
Echovirus3 A-particle in complex with 6D10 Fab
Structural highlights
FunctionPublication Abstract from PubMedEchovirus 3 (E3), a serotype of human enterovirus B (HEV-B), causes severe diseases in infants. Here, we determined the structures of E3 with a monoclonal antibody (MAb) 6D10 by cryo-EM to comprehensively understand the specificities and the immunological characteristic of this serotype. The solved cryo-EM structures of the F-, A-, and E-particles of E3 bound with 6D10 revealed the structural features of the virus-antibody interface. Importantly, the structures of E-particles bound with 6D10 revealed for the first time the nature of the C-terminus of VP1 for HEV-Bs at the structural level. The highly immunogenic nature of this region in the E-particles provides new strategies for vaccine development for HEV-Bs. Structural Basis for the Immunogenicity of the C-Terminus of VP1 of Echovirus 3 Revealed by the Binding of a Neutralizing Antibody.,Qi S, Fu W, Fan J, Zhang L, Zheng B, Wang K, Wang X, Zhu L, Li X, Zhang Y Viruses. 2022 Oct 22;14(11):2322. doi: 10.3390/v14112322. PMID:36366420[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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