8jg7

Structural highlights

Function

SDC1_ARATH Catalyzes the biosynthesis of ethanolamine from serine. Highly specific for L-serine and does not attack D-serine, L-phosphoserine, phosphatidylserine, L-histidine L-glutamate L-tyrosine or L-tryptophan. Decarboxylation of free serine is the major source of ethanolamine production in plants and ethanolamine metabolism is crucial for the synthesis of choline, phosphatidylethanolamine (PE) and phosphatidylcholine (PC), and thus for plant growth.^{[1] [2] [3]}

References

1. ↑ Rontein D, Nishida I, Tashiro G, Yoshioka K, Wu WI, Voelker DR, Basset G, Hanson AD. Plants synthesize ethanolamine by direct decarboxylation of serine using a pyridoxal phosphate enzyme. J Biol Chem. 2001 Sep 21;276(38):35523-9. PMID:11461929 doi:10.1074/jbc.M106038200
2. ↑ Rontein D, Rhodes D, Hanson AD. Evidence from engineering that decarboxylation of free serine is the major source of ethanolamine moieties in plants. Plant Cell Physiol. 2003 Nov;44(11):1185-91. PMID:14634155 doi:10.1093/pcp/pcg144
3. ↑ Kwon Y, Yu SI, Lee H, Yim JH, Zhu JK, Lee BH. Arabidopsis serine decarboxylase mutants implicate the roles of ethanolamine in plant growth and development. Int J Mol Sci. 2012;13(3):3176-3188. PMID:22489147 doi:10.3390/ijms13033176