8jx4

Structural highlights

Function

ENLYS_BPM10 Cysteine protease that cleaves the cell wall of its host methanogen under hydrogen limitation of the latter (autolysis) (PubMed:11544247, PubMed:11934493). Cleaves the epsilon-Ala-Lys isopeptide bond in the oligopeptides of pseudomurein (PubMed:11934493).^{[1] [2]}

References

1. ↑ Luo Y, Pfister P, Leisinger T, Wasserfallen A. The genome of archaeal prophage PsiM100 encodes the lytic enzyme responsible for autolysis of Methanothermobacter wolfeii. J Bacteriol. 2001 Oct;183(19):5788-92. PMID:11544247 doi:10.1128/JB.183.19.5788-5792.2001
2. ↑ Luo Y, Pfister P, Leisinger T, Wasserfallen A. Pseudomurein endoisopeptidases PeiW and PeiP, two moderately related members of a novel family of proteases produced in Methanothermobacter strains. FEMS Microbiol Lett. 2002 Feb 19;208(1):47-51. PMID:11934493 doi:10.1111/j.1574-6968.2002.tb11059.x