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Structural highlights

Function

MAO2_ECOLI Catalyzes the decarboxylation of malate to pyruvate (PubMed:17557829). In vitro, shows malolactic enzyme activity in the presence of NADPH. However, it is unlikely that this activity is of relevance in E.coli, which produces little NADPH (PubMed:33824210).^{[1] [2]}

References

1. ↑ Bologna FP, Andreo CS, Drincovich MF. Escherichia coli malic enzymes: two isoforms with substantial differences in kinetic properties, metabolic regulation, and structure. J Bacteriol. 2007 Aug;189(16):5937-46. PMID:17557829 doi:10.1128/JB.00428-07
2. ↑ Hörl M, Fuhrer T, Zamboni N. Bifunctional Malic/Malolactic Enzyme Provides a Novel Mechanism for NADPH-Balancing in Bacillus subtilis. mBio. 2021 Apr 6;12(2):e03438-20. PMID:33824210 doi:10.1128/mBio.03438-20