8oek

Structural highlights

Function

AGRB2_HUMAN Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity).[UniProtKB:Q8CGM1]^{[1] [2]}

References

1. ↑ Okajima D, Kudo G, Yokota H. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. J Recept Signal Transduct Res. 2010 Jun;30(3):143-53. PMID:20367554 doi:10.3109/10799891003671139
2. ↑ Purcell RH, Toro C, Gahl WA, Hall RA. A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity. Hum Mutat. 2017 Dec;38(12):1751-1760. PMID:28891236 doi:10.1002/humu.23336