8qch

Structural highlights

Function

ADAL_HUMAN Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed:21755941, PubMed:29884623). Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A) (PubMed:21755941, PubMed:29884623). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (PubMed:21755941).^{[1] [2]}

References

1. ↑ Murakami E, Bao H, Mosley RT, Du J, Sofia MJ, Furman PA. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate J Med Chem. 2011 Aug 25;54(16):5902-14. PMID:21755941 doi:10.1021/jm200650j
2. ↑ Chen M, Urs MJ, Sánchez-González I, Olayioye MA, Herde M, Witte CP. m(6)A RNA Degradation Products Are Catabolized by an Evolutionarily Conserved N(6)-Methyl-AMP Deaminase in Plant and Mammalian Cells. Plant Cell. 2018 Jul;30(7):1511-1522. PMID:29884623 doi:10.1105/tpc.18.00236