8s2w

Structural highlights

Function

PDX13_ARATH Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.^{[1] [2] [3]}

References

1. ↑ Tambasco-Studart M, Titiz O, Raschle T, Forster G, Amrhein N, Fitzpatrick TB. Vitamin B6 biosynthesis in higher plants. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13687-92. Epub 2005 Sep 12. PMID:16157873 doi:http://dx.doi.org/0506228102
2. ↑ Chen H, Xiong L. Pyridoxine is required for post-embryonic root development and tolerance to osmotic and oxidative stresses. Plant J. 2005 Nov;44(3):396-408. PMID:16236150 doi:http://dx.doi.org/TPJ2538
3. ↑ Tambasco-Studart M, Tews I, Amrhein N, Fitzpatrick TB. Functional analysis of PDX2 from Arabidopsis, a glutaminase involved in vitamin B6 biosynthesis. Plant Physiol. 2007 Jun;144(2):915-25. Epub 2007 Apr 27. PMID:17468224 doi:http://dx.doi.org/10.1104/pp.107.096784