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Structural highlights

Function

MIK2_ARATH Acts as a receptor of SCOOP peptides from Brassicaceae plants regulating multiple processing including plant growth, development and stress responses (PubMed:33514716, PubMed:34535661). Perception of SCOOP peptides induces the association of MIK2 with the coreceptors BAK1/SERK3 and SERK4 and relays the signaling through the activation of receptor-like cytosolic kinases (RLCKs) BIK1 and PBL1 (PubMed:33514716, PubMed:34535661). Also able to detect SCOOP-like proteins (SCOOPL) present in fungal Fusarium spp. and bacterial Comamonadaceae to elicit various immune responses, including growth inhibition, ROS production, calcium Ca(2+) influx, MAPK activation and MYB51 promoter activation in roots, thus being required for resistance to several root pathogens (PubMed:33514716, PubMed:34535661). Involved in the pollen tube perception of the female signal (PubMed:26863186). Required to trigger defense responses toward generalist herbivores such as Spodoptera littoralis, probably via the activation of jasmonate and indole glucosinolate biosynthesis (PubMed:35401621).^{[1] [2] [3] [4]}

References

1. ↑ Wang T, Liang L, Xue Y, Jia PF, Chen W, Zhang MX, Wang YC, Li HJ, Yang WC. A receptor heteromer mediates the male perception of female attractants in plants. Nature. 2016 Mar 10;531(7593):241-4. doi: 10.1038/nature16975. Epub 2016 Feb 10. PMID:26863186 doi:http://dx.doi.org/10.1038/nature16975
2. ↑ Rhodes J, Yang H, Moussu S, Boutrot F, Santiago J, Zipfel C. Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2. Nat Commun. 2021 Jan 29;12(1):705. PMID:33514716 doi:10.1038/s41467-021-20932-y
3. ↑ Hou S, Liu D, Huang S, Luo D, Liu Z, Xiang Q, Wang P, Mu R, Han Z, Chen S, Chai J, Shan L, He P. The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes. Nat Commun. 2021 Sep 17;12(1):5494. PMID:34535661 doi:10.1038/s41467-021-25580-w
4. ↑ Stahl E, Fernandez Martin A, Glauser G, Guillou MC, Aubourg S, Renou JP, Reymond P. The MIK2/SCOOP Signaling System Contributes to Arabidopsis Resistance Against Herbivory by Modulating Jasmonate and Indole Glucosinolate Biosynthesis. Front Plant Sci. 2022 Mar 23;13:852808. PMID:35401621 doi:10.3389/fpls.2022.852808