8wx2

Structural highlights

Function

S15A3_HUMAN Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693, PubMed:31254495). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).[UniProtKB:Q8BPX9]^{[1] [2]}

References

1. ↑ Oppermann H, Heinrich M, Birkemeyer C, Meixensberger J, Gaunitz F. The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells. Amino Acids. 2019 Jul;51(7):999-1008. PMID:31073693 doi:10.1007/s00726-019-02739-w
2. ↑ Wang Y, Li P, Song F, Yang X, Weng Y, Ma Z, Wang L, Jiang H. Substrate Transport Properties of the Human Peptide/Histidine Transporter PHT2 in Transfected MDCK Cells. J Pharm Sci. 2019 Oct;108(10):3416-3424. PMID:31254495 doi:10.1016/j.xphs.2019.06.016