8zg5

Structural highlights

Function

DMS_STREW Catalyzes the cyclization of farnesyl diphosphate (FPP) to drimenyl diphosphate. Cannot use geranylgeranyl diphosphate (GGPP) as substrate.^[1]

References

1. ↑ Pan X, Du W, Zhang X, Lin X, Li FR, Yang Q, Wang H, Rudolf JD, Zhang B, Dong LB. Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase. J Am Chem Soc. 2022 Dec 7;144(48):22067-22074. PMID:36416740 doi:10.1021/jacs.2c09412