9c4o

Structural highlights

Function

PQQU_ECOLI Mediates the TonB-dependent high affinity transport across the outer membrane of pyrroloquinoline quinone (PQQ), a redox cofactor required for the activity of Gcd and Asd dehydrogenases (PubMed:36054785). The uptake process is energised via the TonB-ExbBD complex (PubMed:36054785). Not involved in the transport of an iron-containing substrate under laboratory conditions (PubMed:32355044, PubMed:36054785).^{[1] [2]}

References

1. ↑ Grinter R, Lithgow T. The crystal structure of the TonB-dependent transporter YncD reveals a positively charged substrate-binding site. Acta Crystallogr D Struct Biol. 2020 May 1;76(Pt 5):484-495. doi:, 10.1107/S2059798320004398. Epub 2020 Apr 27. PMID:32355044 doi:http://dx.doi.org/10.1107/S2059798320004398
2. ↑ Hantke K, Friz S. The TonB-dependent uptake of pyrroloquinoline-quinone (PQQ) and secretion of gluconate by Escherichia coli K-12. Mol Microbiol. 2022 Oct;118(4):417-425. PMID:36054785 doi:10.1111/mmi.14975