9cvc

Structural highlights

Disease

CDAN1_HUMAN Congenital dyserythropoietic anemia type I. The disease is caused by variants affecting the gene represented in this entry.

Function

CDAN1_HUMAN May act as a negative regulator of ASF1 in chromatin assembly.^[1]

References

1. ↑ Ask K, Jasencakova Z, Menard P, Feng Y, Almouzni G, Groth A. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. EMBO J. 2012 Apr 18;31(8):2013-23. PMID:22407294 doi:10.1038/emboj.2012.55