9fp4

Structural highlights

Function

FHMAD_MYCTU Catalyzes the coenzyme F420-dependent oxidation of hydroxymycolic acids (H-MAs) to ketomycolic acids (K-MAs), a lipid class making up the mycobacterial pseudo-outer membrane and over one-third of the dry weight of M.tuberculosis (PubMed:24349169). Does not exhibit F420-dependent glucose-6-phosphate dehydrogenase (FGD) activity (PubMed:23110042).^{[1] [2]}

References

1. ↑ Bashiri G, Perkowski EF, Turner AP, Feltcher ME, Braunstein M, Baker EN. Tat-dependent translocation of an F420-binding protein of Mycobacterium tuberculosis. PLoS One. 2012;7(10):e45003. PMID:23110042 doi:10.1371/journal.pone.0045003
2. ↑ Purwantini E, Mukhopadhyay B. Rv0132c of Mycobacterium tuberculosis encodes a coenzyme F420-dependent hydroxymycolic acid dehydrogenase. PLoS One. 2013 Dec 11;8(12):e81985. PMID:24349169 doi:10.1371/journal.pone.0081985