Structural highlights
Function
IRTA_MYCT3 Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:32296173). Has a preference for Fe-MBT over Fe-cMBT (PubMed:32296173). Mycobactins are then reduced by the siderophore interaction domain to facilitate iron release in the bacterial cell (PubMed:32296173). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (PubMed:32296173).[1]
References
- ↑ Arnold FM, Weber MS, Gonda I, Gallenito MJ, Adenau S, Egloff P, Zimmermann I, Hutter CAJ, Hurlimann LM, Peters EE, Piel J, Meloni G, Medalia O, Seeger MA. The ABC exporter IrtAB imports and reduces mycobacterial siderophores. Nature. 2020 Apr;580(7803):413-417. doi: 10.1038/s41586-020-2136-9. Epub 2020 Mar, 25. PMID:32296173 doi:http://dx.doi.org/10.1038/s41586-020-2136-9
